It was first observed in Keshan province in China, and it has since been found in other areas where the selenium level in the soil is low. Keshan results in heart failure and pulmonary endema due to Kashin-Beck disease is a disorder of the bones and joints of the hands and ingers, elbows, knees, and ankles of children and adolescents. It was later found to be prevalent in a wide belt extending from Southwest to Northeast China. However, the rapid development of gut ora in cardiovascular disease combined with omics and big data platforms may promote the The prevalence of Keshan disease in China KD is still a public health issue among the people of the historically severe endemic areas. Definition Keshan disease is a congestive cardiomyopathy probably caused by dietary deficiency of selenium, named after Keshan, where symptoms were first noted. Keshan Disease is a disease of the Heart. 2 Similar cases of cardiomyopathy were reported in HIV-infected patients 3 and in subjects on parenteral nutrition. Selenium is an essential mineral required by the Body. Furthermore, signs and symptoms of Keshan disease may vary on an individual basis for each patient. Diagnosis of Keshan's disease . 1. Later, there were similar reported cases of KD in Japans Nagano prefecture and in the northern mountains of North Korea in the 1950s . Keshan disease, which is a form of selenium deficiency, is characterized by heart damage and development of cardiomyopathy and arrhythmias. Keshan disease is a potentially fatal form of cardiomyopathy (disease of the heart muscle). It was first observed in Keshan province in China, and it has since been found in other areas where the selenium level in the soil is low. Labcorp Launches Companion Diagnostic for PubMed is a searchable database of medical literature and lists journal articles that discuss Keshan disease. The main clinical features of Keshan disease are cardiac insufficiency and enlargement, electrocardiographic changes, and fibrosis. This disease is often fatal and most commonly affects children and women of childbearing age. The clinical manifestations of patients with KD include primarily congestive heart failure, acute heart failure, and cardiac arrhythmia. Keshan disease (KD) is an endemic, highly lethal cardiomyopathy, which was first reported in northeast Chinas Keshan county in 1935. medical advice of their qualified health care professionals before seeking any information related to their particular diagnosis, cure or treatment of a condition or disorder. Keshan disease (KD) is a potentially fatal form of cardiomyopathy (disease of the heart muscle) endemic in certain areas of China. Southeast Siberia and North Korea are other affected areas. Keshan disease is a potentially fatal form of cardiomyopathy (disease of the heart muscle). doi: 10.3390/molecules22050746. NIH GARD Information: Keshan disease. The blood test is designed to measure the adrenocorticotropic hormone (ACTH) in the blood plasma which is often higher in horses with Equine Cushings Disease. Keshan Disease: Causes, Symptom and Treatment 1 Keshan disease was first discovered in Keshan a province in China. 2 Keshan Disease is a condition that is caused to due to a low intake of selenium. 3 When an individual does not get the required amount of selenium, 4 An individual DOI: 10.1056/NEJMcibr1402199. Tibet currently has the highest incidence rate of KBD in China. Background: Keshan disease is an endemic cardiomyopathy of undened causes. In humans, the initial symptoms are nausea, fatigue, and diarrhea. Keshan disease is an endemic cardiomyopathy of undefined causes. Keshan disease (KSD) is an endemic cardiomyopathy unique to China, and patients are mainly found in the narrow and low-selenium zone from the northeast to the southwest of Editors. Symptoms of Keshan Disease include an enlarged heart and higher rate of stroke, cancer, hypertension and cardiovascular disease. Menkes disease (MD) is an inherited condition that impacts the way the body processes copper levels in the body. Keshan Disease, Selenium Deficiency, and the Selenoproteome. However, the rapid development of gut flora in cardiovascular disease combined with omics and big data platforms may promote the discovery of new diagnostic markers and provide new therapeutic Background Keshan disease is an endemic cardiomyopathy of undefined causes. Being involved in the unclear pathogenesis of Keshan disease, a clear diagnosis, and effective treatment cannot be initiated. KashinBeck disease (KBD) is a chronic, endemic type of osteochondropathy (disease of the bone) that is mainly distributed from northeastern to southwestern China, including 15 provinces. Background: Keshan disease is an endemic cardiomyopathy of undefined causes. Keshan disease is a disease of heart muscle (congestive cardiomyopathy) which is potentially fatal. Being involved in the unclear pathogenesis of Keshan disease, a clear diagnosis List of authors. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Even though some possible etiologies, such as viral infection, fungal infection, microelement deficiency, and malnutrition, have Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus, named after Keshan County of Heilongjiang province, Northeast China, where symptoms were first noted. pii: E746. Keshan Disease is a disease of the Heart. The Heart disorder that is caused by Selenium deficiency is Keshan Disease. Selenium is an essential mineral required by the Body. It works as an antioxidant. It is found in the soil and in marine bivalves (such as oysters). Selenium deficiency was identified as a factor in the etiology of heart failure syndromes in areas of very low selenium intakes, such as China, where an endemic selenium-responsive cardiomyopathy is called Keshan disease. Keshan disease: A condition caused by deficiency of the essential mineral selenium. News. The person can also suffer from cataracts, eczema, infections, psoriasis and arthritis. If continued, the person may develop hair and nail brittleness, rash or skin lesions, and nervous system abnormalities. Symptoms of MD usually appear within the first few months of life and include sparse, kinky hair; slow growth (failure to thrive); and seizures. The Heart disorder that is caused by Selenium deficiency is Keshan Disease. These symptoms were later found prevalent in young women and children in a wide belt extending from northeast to southwest China, a region with a selenium-deficient soil. Its clinical symptoms include joint pain, morning stiffness, enlarged and shortened fingers, and deformed, Selenium is an important mineral for many of your body's functions. Keshan's disease is initially diagnosed through the following methods: Medical history - the doctor will ask a series of questions about the severity and duration of symptoms, your diet, when they started and how often they occur ; Being involved in the unclear pathogenesis of Keshan disease, a clear diagnosis, and eective treatment cannot be initiated. It is hard to consider Keshan disease extremely preventable because the only way to ensure that the individual is getting enough selenium would be to test the soil in the area. However, one way that selenium intake can be improved is to increase intake of foods that are rich with selenium. Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease. N Engl J Med 2014; 370:1756-1760. The clinical features are acute or chronic episodes of heart disorder characterized by cardiogenic shock, Growing children with selenium deficiency may develop a slowly progressive, disabling disorder of the joints and bone (Kashin-Beck disease). Keshan disease: A condition caused by deficiency of the essential mineral selenium. For example, selenium deficiency in combination with a second stress (possibly a viral infection) leads to Keshan disease, a cardiomyopathy that occurred in parts of China prior to a government-sponsored selenium supplementation program that began in the 1970s [2,5,8,21]. This disease occurred primarily in the mountainous regions of China, causing heart lesions. Presumably, it occurs due to viral infection by Coxsackie virus and inability of the immune system to fight against it as a result of disrupted functions in which selenium is an essential component. Selenium supplementation, self-management program for chronic KD patients and translation epidemiology of KD surveillance should be strengthened. This disease is caused by selenium deficiency combined with infection with coxsackievirus (the virus responsible for hand, foot, and mouth disease). The disease peaked in 19601970, killing thousands of people. Molecules. Keshan disease (KD) as an endemic, highly lethal cardiomyopathy, first reported in northeast China's Keshan County in 1935. This information is provided by the National Institutes of Health (NIH) Genetic and Rare Diseases Information Center (GARD). Kashin-Beck disease is an endemic, chronic and degenerative osteoarthropathy that occurs primarily in Tibet and other areas of China, Siberia and North Korea. The ICD code E59 is used to code Keshan disease Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus, named after Keshan County of Heilongjiang Keshan disease occurs only in selenium-deicient children and is associated with an enlarged heart and poor heart function. Keshan disease, an endemic cardiomyopathy occurring in low-selenium areas of China and Russia, is associated with low selenium intake and low blood and hair levels, and affects mainly children and women of childbearing age. by doing an EKG of the heart and looking for a cardiomyopathy. Keshan disease (KD) is an endemic, highly lethal cardiomyopathy, which was first reported in northeast Chinas Keshan county in 1935. Keshan disease damages the walls of the heart, resulting in cardiomyopathy. Kashin-Beck disease: A disorder of the bones and joints of the hands and fingers, elbows, knees, and ankles of children and adolescents who slowly develop stiff deformed joints, shortened limb length and short stature due to necrosis (death) of the growth plates of bones and of joint cartilage. Diagnosis of Keshan Disease is done by the doctor by checking out cardiomyopathy and doing an EKG of the heart. This disease may be more common in Siberia and China. The disease gets its name from the place Keshan County located in China where its symptoms were first diagnosed. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Keshan disease symptoms. Researchers believe this happened in the cases of Keshan disease, which gained attention after affecting a region of China where the soil was particularly deficient in selenium. It was first noted in the Keshan province in Heilongjiang, China. A doctor will be able to diagnosis Kehan disease by doing an EKG of the heart and looking for a cardiomyopathy. In order for doctors to verify that a deficiency in selenium is a cause they will evaluate an individuals blood level. A hair analysis might also be conducted to check for the levels of selenium. Being involved in the unclear pathogenesis of Keshan disease, a clear diagnosis, and effective treatment cannot be initiated. Keshan disease damages the walls of the heart, resulting in cardiomyopathy. Keshan disease is a deficiency condition caused by the dietary deficiency of selenium. Joseph Loscalzo, M.D., Ph.D. May 1, 2014. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus, named after Keshan County of Heilongjiang province, Northeast China, where symptoms The questionable selenium deficiency is Keshan disease. It works as an antioxidant. Visit the website to explore the biology of this condition. These symptoms were later found prevalent in a wide belt extending from northeast to southwest China, all due to selenium-deficient soil. 2017 May 8;22(5). Growing children with selenium deficiency may develop a slowly progressive, disabling disorder of the joints and bone (Kashin-Beck disease). In the past the disease was diagnosed by clinical symptoms alone and while these are still used in part to visually diagnose the disease a blood test can be carried out to confirm it. Learn more about the signs of selenium deficiency and why it might become a bigger health issue in the future. MD primarily affects the nervous system and connective tissue with symptoms that tend to get worse over time. Symptoms may also include chest pain, muscle pain, nausea, vomiting and a decrease in the function of the pancreas. Three speciic diseases have been associated with selenium deiciency. One of the primary symptoms of Keshan disease is an enlarged or inflamed heart muscle, known as congestive cardiomyopathy, which becomes visible via a cardiology examination.

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